Understanding the PULSAR Effect in Combined Radiotherapy and Immunotherapy through Attention Mechanisms with a Transformer Model

Hao Peng, Casey Moore, Debabrata Saha, Steve Jiang, Robert Timmerman
3/7/2024
physics.med-phcs.AI

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Abstract

PULSAR (personalized, ultra-fractionated stereotactic adaptive radiotherapy) is the adaptation of stereotactic ablative radiotherapy towards personalized cancer management. For the first time, we applied a transformer-based attention mechanism to investigate the underlying interactions between combined PULSAR and PD-L1 blockade immunotherapy based on a murine cancer model (Lewis Lung Carcinoma, LLC). The proposed approach is able to predict the trend of tumor volume change semi-quantitatively, and excels in identifying the potential causal relationships through both self-attention and cross-attention scores.

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Cite this paper

@article{peng2024understanding,
  title  = {Understanding the PULSAR Effect in Combined Radiotherapy and Immunotherapy through Attention Mechanisms with a Transformer Model},
  author = {Hao Peng and Casey Moore and Debabrata Saha and Steve Jiang and Robert Timmerman},
  year   = {2024},
  eprint = {2403.04175},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2403.04175v1}
}

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