EPIDetect: Video-based convulsive seizure detection in chronic epilepsy mouse model for anti-epilepsy drug screening

Junming Ren, Zhoujian Xiao, Yujia Zhang, Yujie Yang, Ling He +6 more
5/31/2024
cs.CV

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Abstract

In the preclinical translational studies, drug candidates with remarkable anti-epileptic efficacy demonstrate long-term suppression of spontaneous recurrent seizures (SRSs), particularly convulsive seizures (CSs), in mouse models of chronic epilepsy. However, the current methods for monitoring CSs have limitations in terms of invasiveness, specific laboratory settings, high cost, and complex operation, which hinder drug screening efforts. In this study, a camera-based system for automated detection of CSs in chronically epileptic mice is first established to screen potential anti-epilepsy drugs.

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Cite this paper

@article{ren2024epidetect,
  title  = {EPIDetect: Video-based convulsive seizure detection in chronic epilepsy mouse model for anti-epilepsy drug screening},
  author = {Junming Ren and Zhoujian Xiao and Yujia Zhang and Yujie Yang and Ling He and Ezra Yoon and Stephen Temitayo Bello and Xi Chen and Dapeng Wu and Micky Tortorella and Jufang He},
  year   = {2024},
  eprint = {2405.20614},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2405.20614v1}
}

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