Pareto-Optimized Open-Source LLMs for Healthcare via Context Retrieval

Abstract

This study leverages optimized context retrieval to enhance open-source Large Language Models (LLMs) for cost-effective, high performance healthcare AI. We demonstrate that this approach achieves state-of-the-art accuracy on medical question answering at a fraction of the cost of proprietary models, significantly improving the cost-accuracy Pareto frontier on the MedQA benchmark. Key contributions include: (1) OpenMedQA, a novel benchmark revealing a performance gap in open-ended medical QA compared to multiple-choice formats; (2) a practical, reproducible pipeline for context retrieval optimization; and (3) open-source resources (Prompt Engine, CoT/ToT/Thinking databases) to empower healthcare AI development. By advancing retrieval techniques and QA evaluation, we enable more affordable and reliable LLM solutions for healthcare.