Panacea: Mitigating Harmful Fine-tuning for Large Language Models via Post-fine-tuning Perturbation

Yibo Wang, Tiansheng Huang, Li Shen, Huanjin Yao, Haotian Luo +4 more
1/30/2025
cs.CLcs.AI

Official code: w-yibo/Panacea (14 stars, last commit 2025-11-13).

Abstract

Harmful fine-tuning attack introduces significant security risks to the fine-tuning services. Main-stream defenses aim to vaccinate the model such that the later harmful fine-tuning attack is less effective. However, our evaluation results show that such defenses are fragile--with a few fine-tuning steps, the model still can learn the harmful knowledge. To this end, we do further experiment and find that an embarrassingly simple solution--adding purely random perturbations to the fine-tuned model, can recover the model from harmful behaviors, though it leads to a degradation in the model's fine-tuning performance. To address the degradation of fine-tuning performance, we further propose Panacea, which optimizes an adaptive perturbation that will be applied to the model after fine-tuning. Panacea maintains model's safety alignment performance without compromising downstream fine-tuning performance. Comprehensive experiments are conducted on different harmful ratios, fine-tuning tasks and mainstream LLMs, where the average harmful scores are reduced by up-to 21.2%, while maintaining fine-tuning performance. As a by-product, we analyze the adaptive perturbation and show that different layers in various LLMs have distinct safety affinity, which coincide with finding from several previous study. Source code available at https://github.com/w-yibo/Panacea.

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Code Implementations(1)

w-yibo/PanaceaOfficial100%

[NeurIPS 2025] Panacea: Mitigating Harmful Fine-tuning for Large Language Models via Post-fine-tuning Perturbation.

140Shell, PythonJan 28, 202511 months ago

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Cite this paper

@article{wang2025panacea,
  title  = {Panacea: Mitigating Harmful Fine-tuning for Large Language Models via Post-fine-tuning Perturbation},
  author = {Yibo Wang and Tiansheng Huang and Li Shen and Huanjin Yao and Haotian Luo and Rui Liu and Naiqiang Tan and Jiaxing Huang and Dacheng Tao},
  year   = {2025},
  eprint = {2501.18100},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2501.18100v2}
}

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