Performance of Large Language Models in Supporting Medical Diagnosis and Treatment

Diogo Sousa, Guilherme Barbosa, Catarina Rocha, Dulce Oliveira
4/14/2025
cs.CLcs.AIcs.ET

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Abstract

The integration of Large Language Models (LLMs) into healthcare holds significant potential to enhance diagnostic accuracy and support medical treatment planning. These AI-driven systems can analyze vast datasets, assisting clinicians in identifying diseases, recommending treatments, and predicting patient outcomes. This study evaluates the performance of a range of contemporary LLMs, including both open-source and closed-source models, on the 2024 Portuguese National Exam for medical specialty access (PNA), a standardized medical knowledge assessment. Our results highlight considerable variation in accuracy and cost-effectiveness, with several models demonstrating performance exceeding human benchmarks for medical students on this specific task. We identify leading models based on a combined score of accuracy and cost, discuss the implications of reasoning methodologies like Chain-of-Thought, and underscore the potential for LLMs to function as valuable complementary tools aiding medical professionals in complex clinical decision-making.

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@article{sousa2025performance,
  title  = {Performance of Large Language Models in Supporting Medical Diagnosis and Treatment},
  author = {Diogo Sousa and Guilherme Barbosa and Catarina Rocha and Dulce Oliveira},
  year   = {2025},
  eprint = {2504.10405},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2504.10405v1}
}

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