ChatEXAONEPath: An Expert-level Multimodal Large Language Model for Histopathology Using Whole Slide Images

Abstract

Recent studies have made significant progress in developing large language models (LLMs) in the medical domain, which can answer expert-level questions and demonstrate the potential to assist clinicians in real-world clinical scenarios. Studies have also witnessed the importance of integrating various modalities with the existing LLMs for a better understanding of complex clinical contexts, which are innately multi-faceted by nature. Although studies have demonstrated the ability of multimodal LLMs in histopathology to answer questions from given images, they lack in understanding of thorough clinical context due to the patch-level data with limited information from public datasets. Thus, developing WSI-level MLLMs is significant in terms of the scalability and applicability of MLLMs in histopathology. In this study, we introduce an expert-level MLLM for histopathology using WSIs, dubbed as ChatEXAONEPath. We present a retrieval-based data generation pipeline using 10,094 pairs of WSIs and histopathology reports from The Cancer Genome Atlas (TCGA). We also showcase an AI-based evaluation protocol for a comprehensive understanding of the medical context from given multimodal information and evaluate generated answers compared to the original histopathology reports. We demonstrate the ability of diagnosing the given histopathology images using ChatEXAONEPath with the acceptance rate of 62.9% from 1,134 pairs of WSIs and reports. Our proposed model can understand pan-cancer WSIs and clinical context from various cancer types. We argue that our proposed model has the potential to assist clinicians by comprehensively understanding complex morphology of WSIs for cancer diagnosis through the integration of multiple modalities.