Revolutionizing Clinical Trials: A Manifesto for AI-Driven Transformation

Mihaela van der Schaar, Richard Peck, Eoin McKinney, Jim Weatherall, Stuart Bailey +13 more
6/10/2025
cs.CYcs.AI

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Abstract

This manifesto represents a collaborative vision forged by leaders in pharmaceuticals, consulting firms, clinical research, and AI. It outlines a roadmap for two AI technologies - causal inference and digital twins - to transform clinical trials, delivering faster, safer, and more personalized outcomes for patients. By focusing on actionable integration within existing regulatory frameworks, we propose a way forward to revolutionize clinical research and redefine the gold standard for clinical trials using AI.

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Cite this paper

@article{schaar2025revolutionizing,
  title  = {Revolutionizing Clinical Trials: A Manifesto for AI-Driven Transformation},
  author = {Mihaela van der Schaar and Richard Peck and Eoin McKinney and Jim Weatherall and Stuart Bailey and Justine Rochon and Chris Anagnostopoulos and Pierre Marquet and Anthony Wood and Nicky Best and Harry Amad and Julianna Piskorz and Krzysztof Kacprzyk and Rafik Salama and Christina Gunther and Francesca Frau and Antoine Pugeat and Ramon Hernandez},
  year   = {2025},
  eprint = {2506.09102},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2506.09102v1}
}

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