New Insights on Unfolding and Fine-tuning Quantum Federated Learning

Abstract

Client heterogeneity poses significant challenges to the performance of Quantum Federated Learning (QFL). To overcome these limitations, we propose a new approach leveraging deep unfolding, which enables clients to autonomously optimize hyperparameters, such as learning rates and regularization factors, based on their specific training behavior. This dynamic adaptation mitigates overfitting and ensures robust optimization in highly heterogeneous environments where standard aggregation methods often fail. Our framework achieves approximately 90% accuracy, significantly outperforming traditional methods, which typically yield around 55% accuracy, as demonstrated through real-time training on IBM quantum hardware and Qiskit Aer simulators. By developing self adaptive fine tuning, the proposed method proves particularly effective in critical applications such as gene expression analysis and cancer detection, enhancing diagnostic precision and predictive modeling within quantum systems. Our results are attributed to convergence-aware, learnable optimization steps intrinsic to the deep unfolded framework, which maintains the generalization. Hence, this study addresses the core limitations of conventional QFL, streamlining its applicability to any complex challenges such as healthcare and genomic research.