Bi-cephalic self-attended model to classify Parkinson's disease patients with freezing of gait

Abstract

Parkinson Disease (PD) often results in motor and cognitive impairments, including gait dysfunction, particularly in patients with freezing of gait (FOG). Current detection methods are either subjective or reliant on specialized gait analysis tools. This study aims to develop an objective, data-driven, and multi-modal classification model to detect gait dysfunction in PD patients using resting-state EEG signals combined with demographic and clinical variables. We utilized a dataset of 124 participants: 42 PD patients with FOG (PDFOG+), 41 without FOG (PDFOG-), and 41 age-matched healthy controls. Features extracted from resting-state EEG and descriptive variables (age, education, disease duration) were used to train a novel Bi-cephalic Self-Attention Model (BiSAM). We tested three modalities: signal-only, descriptive-only, and multi-modal, across different EEG channel subsets (BiSAM-63, -16, -8, and -4). Signal-only and descriptive-only models showed limited performance, achieving a maximum accuracy of 55% and 68%, respectively. In contrast, the multi-modal models significantly outperformed both, with BiSAM-8 and BiSAM-4 achieving the highest classification accuracy of 88%. These results demonstrate the value of integrating EEG with objective descriptive features for robust PDFOG+ detection. This study introduces a multi-modal, attention-based architecture that objectively classifies PDFOG+ using minimal EEG channels and descriptive variables. This approach offers a scalable and efficient alternative to traditional assessments, with potential applications in routine clinical monitoring and early diagnosis of PD-related gait dysfunction.