AutoML-Med: A Framework for Automated Machine Learning in Medical Tabular Data

Riccardo Francia, Maurizio Leone, Giorgio Leonardi, Stefania Montani, Marzio Pennisi +2 more
8/4/2025
cs.LGcs.AI

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Abstract

Medical datasets are typically affected by issues such as missing values, class imbalance, a heterogeneous feature types, and a high number of features versus a relatively small number of samples, preventing machine learning models from obtaining proper results in classification and regression tasks. This paper introduces AutoML-Med, an Automated Machine Learning tool specifically designed to address these challenges, minimizing user intervention and identifying the optimal combination of preprocessing techniques and predictive models. AutoML-Med's architecture incorporates Latin Hypercube Sampling (LHS) for exploring preprocessing methods, trains models using selected metrics, and utilizes Partial Rank Correlation Coefficient (PRCC) for fine-tuned optimization of the most influential preprocessing steps. Experimental results demonstrate AutoML-Med's effectiveness in two different clinical settings, achieving higher balanced accuracy and sensitivity, which are crucial for identifying at-risk patients, compared to other state-of-the-art tools. AutoML-Med's ability to improve prediction results, especially in medical datasets with sparse data and class imbalance, highlights its potential to streamline Machine Learning applications in healthcare.

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@article{francia2025automlmed,
  title  = {AutoML-Med: A Framework for Automated Machine Learning in Medical Tabular Data},
  author = {Riccardo Francia and Maurizio Leone and Giorgio Leonardi and Stefania Montani and Marzio Pennisi and Manuel Striani and Sandra D'Alfonso},
  year   = {2025},
  eprint = {2508.02625},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2508.02625v1}
}

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