Performance Assessment Strategies for Generative AI Applications in Healthcare

Victor Garcia, Mariia Sidulova, Aldo Badano
9/9/2025
cs.LGcs.AI

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Abstract

Generative artificial intelligence (GenAI) represent an emerging paradigm within artificial intelligence, with applications throughout the medical enterprise. Assessing GenAI applications necessitates a comprehensive understanding of the clinical task and awareness of the variability in performance when implemented in actual clinical environments. Presently, a prevalent method for evaluating the performance of generative models relies on quantitative benchmarks. Such benchmarks have limitations and may suffer from train-to-the-test overfitting, optimizing performance for a specified test set at the cost of generalizability across other task and data distributions. Evaluation strategies leveraging human expertise and utilizing cost-effective computational models as evaluators are gaining interest. We discuss current state-of-the-art methodologies for assessing the performance of GenAI applications in healthcare and medical devices.

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@article{garcia2025performance,
  title  = {Performance Assessment Strategies for Generative AI Applications in Healthcare},
  author = {Victor Garcia and Mariia Sidulova and Aldo Badano},
  year   = {2025},
  eprint = {2509.08087},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2509.08087v1}
}

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