Personalized Federated Fine-Tuning of Vision Foundation Models for Healthcare

Adam Tupper, Christian Gagné
10/14/2025
cs.CVcs.DC

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Abstract

Foundation models open up new possibilities for the use of AI in healthcare. However, even when pre-trained on health data, they still need to be fine-tuned for specific downstream tasks. Furthermore, although foundation models reduce the amount of training data required to achieve good performance, obtaining sufficient data is still a challenge. This is due, in part, to restrictions on sharing and aggregating data from different sources to protect patients' privacy. One possible solution to this is to fine-tune foundation models via federated learning across multiple participating clients (i.e., hospitals, clinics, etc.). In this work, we propose a new personalized federated fine-tuning method that learns orthogonal LoRA adapters to disentangle general and client-specific knowledge, enabling each client to fully exploit both their own data and the data of others. Our preliminary results on real-world federated medical imaging tasks demonstrate that our approach is competitive against current federated fine-tuning methods.

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@article{tupper2025personalized,
  title  = {Personalized Federated Fine-Tuning of Vision Foundation Models for Healthcare},
  author = {Adam Tupper and Christian Gagné},
  year   = {2025},
  eprint = {2510.12741},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2510.12741v1}
}

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