FairGRPO: Fair Reinforcement Learning for Equitable Clinical Reasoning

Abstract

Medical artificial intelligence systems have achieved remarkable diagnostic capabilities, yet they consistently exhibit performance disparities across demographic groups, causing real-world harm to underrepresented populations. While recent multimodal reasoning foundation models have advanced clinical diagnosis through integrated analysis of diverse medical data, reasoning trainings via reinforcement learning inherit and often amplify biases present in training datasets dominated by majority populations. We introduce Fairness-aware Group Relative Policy Optimization (FairGRPO), a hierarchical reinforcement learning approach that promotes equitable learning across heterogeneous clinical populations. FairGRPO employs adaptive importance weighting of advantages based on representation, task difficulty, and data source. To address the common issue of missing demographic labels in the clinical domain, we further employ unsupervised clustering, which automatically discovers latent demographic groups when labels are unavailable. Through comprehensive experiments across 7 clinical diagnostic datasets spanning 5 clinical modalities across X-ray, CT scan, dermoscropy, mammography and ultrasound, we demonstrate that FairGRPO reduces predictive parity by 27.2% against all vanilla and bias mitigated RL baselines, while improving F1 score by 12.49%. Furthermore, training dynamics analysis reveals that FairGRPO progressively improves fairness throughout optimization, while baseline RL methods exhibit deteriorating fairness as training progresses. Based on FairGRPO, we release FairMedGemma-4B, a fairness-aware clinical VLLM that achieves state-of-the-art performance while demonstrating significantly reduced disparities across demographic groups.