Fast Voxel-Wise Kinetic Modeling in Dynamic PET using a Physics-Informed CycleGAN

Christian Salomonsen, Samuel Kuttner, Michael Kampffmeyer, Robert Jenssen, Kristoffer Wickstrøm +2 more
10/27/2025
cs.CVq-bio.OT

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Abstract

Tracer kinetic modeling serves a vital role in diagnosis, treatment planning, tracer development and oncology, but burdens practitioners with complex and invasive arterial input function estimation (AIF). We adopt a physics-informed CycleGAN showing promise in DCE-MRI quantification to dynamic PET quantification. Our experiments demonstrate sound AIF predictions and parameter maps closely resembling the reference.

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Cite this paper

@article{salomonsen2025fast,
  title  = {Fast Voxel-Wise Kinetic Modeling in Dynamic PET using a Physics-Informed CycleGAN},
  author = {Christian Salomonsen and Samuel Kuttner and Michael Kampffmeyer and Robert Jenssen and Kristoffer Wickstrøm and Jong Chul Ye and Elisabeth Wetzer},
  year   = {2025},
  eprint = {2510.23140},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2510.23140v1}
}

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