Melanoma Classification Through Deep Ensemble Learning and Explainable AI

Wadduwage Shanika Perera, ABM Islam, Van Vung Pham, Min Kyung An
10/31/2025
cs.LGcs.CV

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Abstract

Melanoma is one of the most aggressive and deadliest skin cancers, leading to mortality if not detected and treated in the early stages. Artificial intelligence techniques have recently been developed to help dermatologists in the early detection of melanoma, and systems based on deep learning (DL) have been able to detect these lesions with high accuracy. However, the entire community must overcome the explainability limit to get the maximum benefit from DL for diagnostics in the healthcare domain. Because of the black box operation's shortcomings in DL models' decisions, there is a lack of reliability and trust in the outcomes. However, Explainable Artificial Intelligence (XAI) can solve this problem by interpreting the predictions of AI systems. This paper proposes a machine learning model using ensemble learning of three state-of-the-art deep transfer Learning networks, along with an approach to ensure the reliability of the predictions by utilizing XAI techniques to explain the basis of the predictions.

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Cite this paper

@article{perera2025melanoma,
  title  = {Melanoma Classification Through Deep Ensemble Learning and Explainable AI},
  author = {Wadduwage Shanika Perera and ABM Islam and Van Vung Pham and Min Kyung An},
  year   = {2025},
  eprint = {2511.00246},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2511.00246v1}
}

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