Evaluating the Challenges of LLMs in Real-world Medical Follow-up: A Comparative Study and An Optimized Framework

Jinyan Liu, Zikang Chen, Qinchuan Wang, Tan Xie, Heming Zheng +1 more
12/22/2025
cs.CLcs.AI

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Abstract

When applied directly in an end-to-end manner to medical follow-up tasks, Large Language Models (LLMs) often suffer from uncontrolled dialog flow and inaccurate information extraction due to the complexity of follow-up forms. To address this limitation, we designed and compared two follow-up chatbot systems: an end-to-end LLM-based system (control group) and a modular pipeline with structured process control (experimental group). Experimental results show that while the end-to-end approach frequently fails on lengthy and complex forms, our modular method-built on task decomposition, semantic clustering, and flow management-substantially improves dialog stability and extraction accuracy. Moreover, it reduces the number of dialogue turns by 46.73% and lowers token consumption by 80% to 87.5%. These findings highlight the necessity of integrating external control mechanisms when deploying LLMs in high-stakes medical follow-up scenarios.

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Cite this paper

@article{liu2025evaluating,
  title  = {Evaluating the Challenges of LLMs in Real-world Medical Follow-up: A Comparative Study and An Optimized Framework},
  author = {Jinyan Liu and Zikang Chen and Qinchuan Wang and Tan Xie and Heming Zheng and Xudong Lv},
  year   = {2025},
  eprint = {2512.18999},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2512.18999v1}
}

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