M3CoTBench: Benchmark Chain-of-Thought of MLLMs in Medical Image Understanding

Juntao Jiang, Jiangning Zhang, Yali Bi, Jinsheng Bai, Weixuan Liu +5 more
1/13/2026
eess.IVcs.CV

No official code found. Best implementation: juntaoJianggavin/M3CoTBench (29 stars, last commit 2026-01-14).

Abstract

Chain-of-Thought (CoT) reasoning has proven effective in enhancing large language models by encouraging step-by-step intermediate reasoning, and recent advances have extended this paradigm to Multimodal Large Language Models (MLLMs). In the medical domain, where diagnostic decisions depend on nuanced visual cues and sequential reasoning, CoT aligns naturally with clinical thinking processes. However, Current benchmarks for medical image understanding generally focus on the final answer while ignoring the reasoning path. An opaque process lacks reliable bases for judgment, making it difficult to assist doctors in diagnosis. To address this gap, we introduce a new M3CoTBench benchmark specifically designed to evaluate the correctness, efficiency, impact, and consistency of CoT reasoning in medical image understanding. M3CoTBench features 1) a diverse, multi-level difficulty dataset covering 24 examination types, 2) 13 varying-difficulty tasks, 3) a suite of CoT-specific evaluation metrics (correctness, efficiency, impact, and consistency) tailored to clinical reasoning, and 4) a performance analysis of multiple MLLMs. M3CoTBench systematically evaluates CoT reasoning across diverse medical imaging tasks, revealing current limitations of MLLMs in generating reliable and clinically interpretable reasoning, and aims to foster the development of transparent, trustworthy, and diagnostically accurate AI systems for healthcare. Project page at https://juntaojianggavin.github.io/projects/M3CoTBench/.

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@article{jiang2026mcotbench,
  title  = {M3CoTBench: Benchmark Chain-of-Thought of MLLMs in Medical Image Understanding},
  author = {Juntao Jiang and Jiangning Zhang and Yali Bi and Jinsheng Bai and Weixuan Liu and Weiwei Jin and Zhucun Xue and Yong Liu and Xiaobin Hu and Shuicheng Yan},
  year   = {2026},
  eprint = {2601.08758},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2601.08758v2}
}

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