What Patients Really Ask: Exploring the Effect of False Assumptions in Patient Information Seeking

Raymond Xiong, Furong Jia, Lionel Wong, Monica Agrawal
1/22/2026
cs.CL

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Abstract

Patients are increasingly using large language models (LLMs) to seek answers to their healthcare-related questions. However, benchmarking efforts in LLMs for question answering often focus on medical exam questions, which differ significantly in style and content from the questions patients actually raise in real life. To bridge this gap, we sourced data from Google's People Also Ask feature by querying the top 200 prescribed medications in the United States, curating a dataset of medical questions people commonly ask. A considerable portion of the collected questions contains incorrect assumptions and dangerous intentions. We demonstrate that the emergence of these corrupted questions is not uniformly random and depends heavily on the degree of incorrectness in the history of questions that led to their appearance. Current LLMs that perform strongly on other benchmarks struggle to identify incorrect assumptions in everyday questions.

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Cite this paper

@article{xiong2026what,
  title  = {What Patients Really Ask: Exploring the Effect of False Assumptions in Patient Information Seeking},
  author = {Raymond Xiong and Furong Jia and Lionel Wong and Monica Agrawal},
  year   = {2026},
  eprint = {2601.15674},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2601.15674v1}
}

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