Evidence-Anchored Overdose Death Prediction from Death Investigation Reports

Raavi Gupta, Ziqing Yang, Karli R. Hochstatter, Talia Nadel, Nicole D'Anna +6 more
10/14/2026
cs.CLcs.AIcs.LG

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Abstract

Confirmation of overdose deaths in the United States is often delayed due to the complexities of certifying drug-involved deaths. Death investigation reports represent a rich but underutilized data source that could be used to predict whether a death is a suspected overdose (i.e., a death preliminarily identified as an overdose prior to the final cause and manner of death determination). We present an automated framework that classifies suspected overdoses from death investigation reports, while producing supporting explanations guided by expert knowledge. Through an expert-guided design process, we investigate 1) what type of explanations are best for model prediction performance, and 2) which architecture is better suited for this task: pipeline models that rationalize first and then predict, or self-rationalizing models that jointly predict and rationalize? Our experiments show that a pipeline model with explanations grounded in the input death investigation reports outperforms the other settings. Our best model also outperforms a rule-based system currently in deployment by 15%, while allowing expert interventions for final decisions.

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Cite this paper

@article{gupta2026evidenceanchored,
  title  = {Evidence-Anchored Overdose Death Prediction from Death Investigation Reports},
  author = {Raavi Gupta and Ziqing Yang and Karli R. Hochstatter and Talia Nadel and Nicole D'Anna and Jason K. Graham and Hannah Johnson and Kelsey Opozda and Nabila El-Bassel and Anubhav Jangra and Smaranda Muresan},
  year   = {2026},
  eprint = {2610.19556},
  archivePrefix = {arXiv},
  url    = {http://arxiv.org/abs/2610.19556v1}
}

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