Healthcare AI

Over the last decades, many prognostic models based on artificial intelligence techniques have been used to provide detailed predictions in healthcare. Unfortunately, the real-world observational data used to train and validate these models are almost always affected by biases that can strongly impact the outcomes validity: two examples are values missing not-at-random and selection bias. Addressing them is a key element in achieving transportability and in studying the causal relationships that...

Background: Large language models (LLMs) are rapidly being integrated into healthcare, promising to enhance various clinical tasks. However, concerns exist regarding their potential for bias, which could compromise patient care and exacerbate health inequities. This systematic review investigates the prevalence, sources, manifestations, and clinical implications of bias in LLMs. Methods: We conducted a systematic search of PubMed, OVID, and EMBASE from database inception through 2025, for studie...

We introduce AraHealthQA 2025, the Comprehensive Arabic Health Question Answering Shared Task, held in conjunction with ArabicNLP 2025 (co-located with EMNLP 2025). This shared task addresses the paucity of high-quality Arabic medical QA resources by offering two complementary tracks: MentalQA, focusing on Arabic mental health Q&A (e.g., anxiety, depression, stigma reduction), and MedArabiQ, covering broader medical domains such as internal medicine, pediatrics, and clinical decision making. Eac...

The evaluation of Large Language Models (LLMs) in healthcare has been dominated by physician-centric, English-language benchmarks, creating a dangerous illusion of competence that ignores the interprofessional nature of patient care. To provide a more holistic and realistic assessment, we introduce HealthQA-BR, the first large-scale, system-wide benchmark for Portuguese-speaking healthcare. Comprising 5,632 questions from Brazil's national licensing and residency exams, it uniquely assesses know...

Large Language Models (LLMs) are transforming healthcare through the development of LLM-based agents that can understand, reason about, and assist with medical tasks. This survey provides a comprehensive review of LLM-based agents in medicine, examining their architectures, applications, and challenges. We analyze the key components of medical agent systems, including system profiles, clinical planning mechanisms, medical reasoning frameworks, and external capacity enhancement. The survey covers...

Health AI is evolving from answering questions to agentic systems that converse with patients, reason about health records, and act on their behalf. Primary care guards against diagnostic errors and unsafe care; agents assisting in this domain warrant evaluation against the same risks. Current benchmarks focus on medical knowledge, assessed through isolated question-answering or clinician-facing tasks. PatientAgentBench benchmarks patient-facing agentic healthcare; it evaluates a foundation mode...

With the growing utilization of machine learning in healthcare, there is increasing potential to enhance healthcare outcomes. However, this also brings the risk of perpetuating biases in data and model design that can harm certain demographic groups based on factors such as age, gender, and race. This study proposes an artificial intelligence framework, grounded in software engineering principles, for identifying and mitigating biases in data and models while ensuring fairness in healthcare sett...

This study introduces a novel methodology for modelling patient emotions from online patient experience narratives. We employed metadata network topic modelling to analyse patient-reported experiences from Care Opinion, revealing key emotional themes linked to patient-caregiver interactions and clinical outcomes. We develop a probabilistic, context-specific emotion recommender system capable of predicting both multilabel emotions and binary sentiments using a naive Bayes classifier using context...

Medical Dialogue Systems aim to provide automated healthcare support through patient-agent conversations. Previous efforts typically regard patients as ideal users -- one who accurately and consistently reports their health conditions. However, in reality, patients often misreport their symptoms, leading to discrepancies between their reports and actual health conditions. Overlooking patient misreport will affect the quality of healthcare consultations provided by MDS. To address this issue, we ...

With the advancement of large language models, many dialogue systems are now capable of providing reasonable and informative responses to patients' medical conditions. However, when patients consult their doctor, they may experience negative emotions due to the severity and urgency of their situation. If the model can provide appropriate comfort and empathy based on the patient's negative emotions while answering medical questions, it will likely offer a more reassuring experience during the med...

Ensuring the accuracy of responses provided by large language models (LLMs) is crucial, particularly in clinical settings where incorrect information may directly impact patient health. To address this challenge, we construct K-QA, a dataset containing 1,212 patient questions originating from real-world conversations held on K Health (an AI-driven clinical platform). We employ a panel of in-house physicians to answer and manually decompose a subset of K-QA into self-contained statements. Additio...

The global adoption of Large Language Models (LLMs) in healthcare shows promise to enhance clinical workflows and improve patient outcomes. However, Automatic Speech Recognition (ASR) errors in critical medical terms remain a significant challenge. These errors can compromise patient care and safety if not detected. This study investigates the prevalence and impact of ASR errors in medical transcription in Nigeria, the United Kingdom, and the United States. By evaluating raw and LLM-corrected tr...

This paper presents the overview of the development and fine-tuning of large language models (LLMs) designed specifically for answering medical questions. We are mainly improving the accuracy and efficiency of providing reliable answers to medical queries. In our approach, we have two stages, prediction of a specific label for the received medical question and then providing a predefined answer for this label. Various models such as RoBERTa and BERT were examined and evaluated based on their abi...

Objectives: To evaluate the current limitations of large language models (LLMs) in medical question answering, focusing on the quality of datasets used for their evaluation. Materials and Methods: Widely-used benchmark datasets, including MedQA, MedMCQA, PubMedQA, and MMLU, were reviewed for their rigor, transparency, and relevance to clinical scenarios. Alternatives, such as challenge questions in medical journals, were also analyzed to identify their potential as unbiased evaluation tools. Res...

Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These new LLMs are not just capable of modeling language, but can also act as intelligent "agents" that interact with stakeholders in open-ended conversations and even influence clinical decision-making. Rather than relying on benchmarks that measure a model's ability to process clinical data or answer standardized test questions, LLM agents...

Recent advancements in large language models have demonstrated their potential in numerous medical applications, particularly in automating clinical trial matching for translational research and enhancing medical question answering for clinical decision support. However, our study shows that incorporating non decisive sociodemographic factors such as race, sex, income level, LGBT+ status, homelessness, illiteracy, disability, and unemployment into the input of LLMs can lead to incorrect and harm...

Time series forecasting has applications across domains and industries, especially in healthcare, but the technical expertise required to analyze data, build models, and interpret results can be a barrier to using these techniques. This article presents a web platform that makes the process of analyzing and plotting data, training forecasting models, and interpreting and viewing results accessible to researchers and clinicians. Users can upload data and generate plots to showcase their variables...

Health is a fundamental pillar of human wellness, and the rapid advancements in large language models (LLMs) have driven the development of a new generation of health agents. However, the application of health agents to fulfill the diverse needs of individuals in daily non-clinical settings is underexplored. In this work, we aim to build a comprehensive personal health agent that is able to reason about multimodal data from everyday consumer wellness devices and common personal health records, a...

Large language models (LLMs) are increasingly used to generate summaries from clinical notes. However, their ability to preserve essential diagnostic information remains underexplored, which could lead to serious risks for patient care. This study introduces DistillNote, an evaluation framework for LLM summaries that targets their functional utility by applying the generated summary downstream in a complex clinical prediction task, explicitly quantifying how much prediction signal is retained. W...

In response to the pressing need for advanced clinical problem-solving tools in healthcare, we introduce BooksMed, a novel framework based on a Large Language Model (LLM). BooksMed uniquely emulates human cognitive processes to deliver evidence-based and reliable responses, utilizing the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) framework to effectively quantify evidence strength. For clinical decision-making to be appropriately assessed, an evaluation metric t...